Recent MRI research has revealed compelling evidence about the regenerative effects of Platelet-Rich Plasma (PRP) therapy on knee joints affected by osteoarthritis.
In this study, researchers compared three groups of patients:
• One receiving PRP injections
• One given saline (placebo) injections
• And another evaluated using different centrifuge methods (single vs. double spin) for PRP preparation
The Results: Clear Regeneration Seen on MRI
MRI scans provided direct visual proof of how PRP therapy supports healing within the knee. Patients who received PRP showed slowed degeneration and structural improvement of the joint tissue compared to those who received saline.
This aligns with what we see clinically — PRP doesn’t just mask pain like cortisone injections often do; it actively supports tissue repair and joint regeneration over time.
While cortisone may bring short-term relief, studies have shown that long-term use can accelerate joint degeneration. PRP, on the other hand, promotes lasting recovery and slows down the progression of osteoarthritis.
Single vs. Double Spin PRP — The Surprise Finding
Traditionally, it’s been believed that PRP prepared using a double centrifuge process (to achieve a higher platelet concentration) offers superior results.
However, this MRI-based study found that both single and double spin methods performed equally well in improving knee health and reducing pain.
That’s encouraging news for clinics using a single-spin system — it means effective outcomes can still be achieved without requiring complex or costly preparation methods.
The Bottom Line
• PRP outperformed saline injections significantly in pain relief and knee regeneration.
• Both single and double spin PRP provided comparable benefits.
• MRI evidence confirms that PRP supports structural healing — not just symptom management.
This study reinforces what many clinicians already observe: PRP is one of the most effective, natural approaches for managing osteoarthritis of the knee, offering long-term results and tissue regeneration without the downsides of steroid-based treatments.
